Automated reduction of blood coagulation models

Mathematical and biological models of blood coagulation.

Overview of Mathematical Models for Blood Flow and Coagulation Process

In this paper we introduce the key properties of blood flow and the blood coagulation process which are essential for their mathematical modelling. After this introduction we review possible approaches to the modelling of blood flow. The conditions of blood flow determine the blood coagulation process because blood flow carries chemical reactants to the area of coagulation. We will introduce th...

Mathematical models of blood coagulation and platelet adhesion: clinical applications.

At present, computer-assisted molecular modeling and virtual screening have become effective and widely-used tools for drug design. However, a prerequisite for design and synthesis of a therapeutic agent is determination of a correct target in the metabolic system, which should be either inhibited or stimulated. Solution of this extremely complicated problem can also be assisted by computationa...

Mathematical and biological models of blood coagulation. A rebuttal.

Blood Coagulation

INTRODUCTION This section covers the means, as far as we now know them, by which components of the blood plasma produce an insoluble protein meshwork, or gel, at a site of blood-vessel damage. The plasma is normally completely fluid, containing all its proteins in soluble form. When the clotting system is activated at a site of blood-vessel damage, a series of proteolytic reactions is set going...